msi slotMost M.2 PCIe SSD slots (including combo M.2 slots) support the NVMe protocol but none of the M.2 SATA-only SSD slots support it. NVMe is optional. You can use anB key slot for ‘B’Key card (also known as Socket 2) (SATA) M key slot in ‘M’Key card (also known as Socket 3) (PCIe x 4) B+M Key cassettes are available for both cassette slots. Check HDD and SSD support specifications.